Novel diamide-based inhibitors of IMPDH

Henry H Gu; Edwin J Iwanowicz; Junqing Guo; Scott H Watterson; Zhongqi Shen; William J Pitts; T G Murali Dhar; Catherine A Fleener; Katherine Rouleau; N Z Sherbina; Mark Witmer; Jeffrey Tredup; Diane Hollenbaugh

doi:10.1016/s0960-894x(02)00132-4

Novel diamide-based inhibitors of IMPDH

Bioorg Med Chem Lett. 2002 May 6;12(9):1323-6. doi: 10.1016/s0960-894x(02)00132-4.

Authors

Henry H Gu¹, Edwin J Iwanowicz, Junqing Guo, Scott H Watterson, Zhongqi Shen, William J Pitts, T G Murali Dhar, Catherine A Fleener, Katherine Rouleau, N Z Sherbina, Mark Witmer, Jeffrey Tredup, Diane Hollenbaugh

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. henry.gu@bms.com

PMID: 11965381
DOI: 10.1016/s0960-894x(02)00132-4

Abstract

A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.

MeSH terms

Catalysis
Diamide / chemistry*
Diamide / pharmacology*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
IMP Dehydrogenase / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Diamide
IMP Dehydrogenase